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doi:10.1016/j.sapharm.2016.01.004

Safety FDA found no clinical studies establishing safety, no pharmacokinetic data and no human immunogenicity or aggregation studies

Chiarpotto E, Domenicotti C, Paola D et al (1999) Regulation of rat hepatocyte protein kinase C beta isoenzymes by the lipid peroxidation product 4-hydroxy-2,3-nonenal: a signaling pathway to modulate vesicular transport of glycoproteins