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Similarly, myeloid cell lines (K562-r and LAMA84-r) with aberrant expression of Breakpoint Cluster Region-Breakpoints in the Abelson (ABL)1 fusion (BCR-ABL1) and resistance to imatinib maintain a highly glycolytic metabolic phenotype with elevated lactate production (Xu et al., 2016), and it has an increased glycolytic rate ( In contrast to the above, a single publication by 2.2 Regulation of increased glycolytic flux: intrinsic mechanistic factors Different intrinsic factors have been established that influence an improvement in the glycolytic pathway in chemoresistant leukemia cells (Figure 1)

Molecules 18:1187311903 Pick U, Haramaki N, Constantinescu A, Handelman GJ, Tritschler HJ, Packer L (1995) Glutathione reductase and lipoamide dehydrogenase have opposite stereospecificities for alpha-lipoic acid enantiomers

doi: 10.1016/j.schres.2010.01.011 110

& Thakur, I

Husby S, Foged N, Oxelius VA, Svehag SE