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In addition to these canonical reactions, both enzymes have been proposed to produce H 2 S by utilizing alternative substrates, namely, a combination of cystine and homocysteine for CBS and either cysteine or homocysteine for CSE (Sbodio et al., 2019)

In particular, immune modulatory effects of anti-CD38 antibodies during cancer therapy may be at least in part related to the decrease in CD38 NADase activity

However, 1 O 2 has a brief lifespan and limited diffusion range, restricting its damage within the cell diameter

All these pathological modifications contribute to the pathogenesis of vascular dysfunction