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J Biol Chem 282(28):2041620424 Mato JM, Alvarez L, Ortiz P, Pajares MA (1997) S-adenosylmethionine synthesis: molecular mechanisms and clinical implications

9 Emerging therapeutic interventions targeting metabolism and mitochondria 9.1 Metabolic modulators 9.1.1 Intranasal insulin Central nervous system (CNS) insulin deficiency may result from impaired insulin transport across the blood-brain barrier (BBB)