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(2) If the amount of shared savings earned by the ACO is revised upward by CMS for any reason, CMS will reduce the redetermined amount of shared savings by the amount of prepaid shared savings made to the ACO as of the date of the redetermination

Scientific References TripleHormone-Receptor Agonist Retatrutide for Obesity (Phase 2 Trial)

DOI: 10.1210/jc.2015-3754

The combination of GLP-1 and GIP activation is what separates tirzepatide from pure GLP-1 agonists like semaglutide, and clinical data suggests the dual mechanism produces superior weight loss outcomes