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We performed a post hoc pair-wise (TukeyKramer) comparison adjusting for age, sex, ethnicity and smoking to determine differences between groups

(Lond.) 38 , 63 (2018)

[DOI] [PMC free article] [PubMed] [Google Scholar] 10.Ellies L.G., Johnson A., Olefsky J.M

doi: 10.1016/j.jtemb.2020.126558 96 Rasic-MilutinovicZJovanovicDBogdanovicGTrifunovicJMuticJ

The first double formulation, consisting in a combination of Ivacaftor and Lumacaftor (Orkambi, Vertex Pharmaceuticals Ltd, UK), have been approved in 2015 by FDA and EMA for patients who are homozygous for the F508del CFTR mutation