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C., Bowler, R

doi: 10.1136/ard-2023-225237 44 ZhangBWangYYuanYSunJLiuLHuangDet al

Its importance has produced a crowded supplement market filled with competing claims about absorption, detoxification and longevity

doi: 10.1097/MD.0000000000009438

The nuclear factor erythroid 2-related factor 2 ( NFE2L2 or NRF2) transcription factor is constitutively activated in many cancers and promotes a specific gene expression program involved in cellular detoxification, redox buffering, and metabolic rewiring (Cancer Genome Atlas Research, 2012