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Important note: human safe dosing has not been established for any of these compounds

ATP depletion stimulates PKC-alpha activity and leads to translocation of the enzyme to the plasma membrane, thereby enhancing serine phosphorylation of membrane proteins, such as the Ca 2+ -permeable cation channel (Fig

doi: 10.1128/MCB.26.1.221-229.2006

None of these pathways directly substitute for another, which is part of why researchers interested in a fuller picture of metabolic regulation may look at all three within the same body of literature not to combine effects, but to understand how separate systems might interact at a mechanistic level

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