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Sikiric P, Rucman R, Turkovic B, Sever M, Klicek R, Radic B, et al

2a and Supplementary Table 1, parent K D = 5 nM)

Key Mechanistic Differences# The mechanistic distinction is significant: Dihexa promotes structural synaptic plasticity through growth factor signaling (building new connections), while PE-22-28 modulates functional neuronal properties through ion channel blockade (changing how existing neurons fire)