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They work well for pure cognitive enhancement but do nothing for the anxiety component that limits many peoples mental performance

A review of oxidative stress products and related genes in early Alzheimer's disease

The transcription factor Nrf2 was previously verified to regulate the cellular adaptive response to excessive oxidative stress and inflammation, thereby inhibiting ferroptosis in iron overload-induced liver injury

By stabilizing the complex formed between topoisomerase-II and DNA, they prevent the re-ligation of DNA strand breaks that the enzyme normally creates and resolves, leading to an accumulation of permanent DNA damage