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After that, patients usually continue lifelong maintenance 1000 g once monthly

It took a while to figure out what was going on, but when they reduced her B12 dose to 250mcg three times a week and had her take it in the late morning (when kidneys work best), her symptoms improved and her kidney function stabilized

ClinicalTrials.gov exact-name search, accessed 2026-07-12 ClinicalTrials.gov exact-name search, accessed 2026-07-12

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Patients who do respond meaningfully to the combination may continue cycling AOD-9604 in defined patterns (typically with the 4 to 8 week break between cycles) for as long as the response remains clinically useful