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Glucose enters the cellular milieu through glucose transporter 1 (Glut-1), followed by conversion to pyruvate, which is mediated by a series of enzymatic steps, including glucose phosphorylation to glucose-6-phosphate (G-6-P), followed by conversion to pyruvate, reducing NAD + to NADH and generating ATP molecules via oxidative phosphorylation (OXPHOS) through the mitochondrial electron transport chain (ETC)

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Obesity is a major global health issue connected to several metabolic and cardiovascular disorders

262 In addition, the level of serum FAM19A5 was shown to have a negative correlation with cortical thickness in specific brain regions

Similarly, the enzymatic antioxidant defense is impaired with age, as evidenced by a significant reduction in the activity of SOD-1, catalase and GSH-Px in erythrocytes [Figure 2] [62]