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Compared to other tissues, the brain is more vulnerable and sensitive to oxidative stress

Mechanistically, p53 decreases the monoubiquitination rate of histone H2B on lysine 120 (H2Bub1) in the SLC7A11 gene regulatory region by facilitating the nuclear translocation of the deubiquitinase USP7, leading to the inactivation of SLC7A11 expression in erastin-treated cells [122]

Western blot analysis for histones Histones were purified using the Histone extraction kit from Abcam (Ab113476), according to the manufacturers instructions

The key pathological hallmarks of AD include amyloid-beta (A) plaque accumulation, neurofibrillary tangles of hyperphosphorylated tau, chronic neuroinflammation, oxidative stress, and mitochondrial dysfunction (Lv et al., 2020)

278 ROS-mediated Ca 2+ activation in antitumorigenic signaling involves the potentiation of the Ca 2+ emission channel mucolipin-1 (MCOLN1/TRPML1) through palmitoylation of cysteine residues Cys565, Cys566, and Cys567 within the L564CCC motif on its C-terminal tail