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The gene for the coronavirus spike protein is inserted into an adenovirus that has been modified to render it harmless (it cannot cause COVID-19).Once administered into a muscle in the upper arm this modified adenovirus enters a cell, travels to the nucleus, and inserts the gene for making the spike protein into the host cell DNA

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Hyperglycemia activates the polyol pathway, increasing sorbitol and fructose production, which induces osmotic and oxidative stress in muscle cells

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