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Recent research has shown that CAFs, a significant group of stromal cells in the TME that emit HGF, trigger the HGF/c-MET pathway and its subsequent signals, thereby facilitating tumor movement and advancement

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Discussion Cellular senescence, triggered by diverse external and internal stressors, serves as a protective response that prevents the proliferation of impaired cells, thereby conferring resistance to cancer 45,468

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In skin wounds, LL-37 promotes healing by encouraging keratinocyte migration and proliferation