In this study, we first identified the expression change of GPX1 in mouse cochlea SGNs through the in vitro peroxynitrite-damaged SGNs model, then we investigated the neuroprotective effect of GPX1 against peroxynitrite-induced SGN damage
As a result, defenses against ROS are activated 14 by an array of nonenzymatic antioxidants [metabolites such as ascorbate (AsA), carotenoids, glutathione (GSH) and proline] and antioxidant enzymes [such as guaiacol peroxidases (GPOX), catalase (CAT), superoxide dismutase (SOD) and AsA-GSH cycle enzymes like glutathione reductase (GR) ascorbate peroxidase (APX), monodehydroascorbate reductase (MDHAR), dehydroascorbate reductase (DHAR)], work together for detoxification of ROS 7,8,15,16,17,18,19,20
Under treatment strategies, delivering drug candidate within neural compartment is challenging and is dependent upon leucocytic transmission
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