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Hypoxia fundamentally creates the low oxygen condition responsible for the alteration in Hypoxia-Inducible Factor-1alpha (HIF-1) signaling within the tumor microenvironment, allowing tumors to survive and making them resistant to various therapies

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Take B12 Injections B12 injections of 100 mcg per dose are administered in the muscle or under the skin from 30 mcg to 500 mcg per dose

This protection was manifested by a reduction in DNA damage, highlighting the role of selenium in safeguarding cells from the genotoxic effects of these platinum-based chemotherapeutic agents (160)

Effect sizes modest, approximately 30-50% better preservation versus controls