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This process triggers inflammation, apoptosis, DNA damage, lipid peroxidation, and mitochondrial dysfunction, contributing to disorders, including metabolic cardiovascular diseases, Alzheimers and Parkinsons diseases, premature aging, and certain cancers (Kozarski et al

Bull MJ, Plummer NT (2014) Part 1: the human gut microbiome in health and disease

All of them had central nervous system involvement with evolution into spastic tetraparesis and a declining clinical condition

We also integrated the latest developments obtained on the role of receptor trafficking in desensitization and tolerance and the concept of biased agonism