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Description

The primary metabolite, phosphoramide mustard, is a nitrogen mustard molecule considered the most therapeutically effective metabolite owing to its significant ability to induce DNA damage by intercalating between the two strands (Vredenburg et al

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Of note, p62 is particularly interesting, since it is the most studied non-canonical pathway of Nrf2 activation

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Muscle Cell and Tissue (InTech, 2015)

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doi: 10.3390/antibiotics8040269 22 MaloneyEL

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