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This aligns with the fact that overexpression of PPAR coactivator 1-alpha (PGC-1), a regulator of mitochondrial biogenesis, increases the generation of CD8 central memory T cells and, in general, improves murine immune responses following infection, immunization, and in the generation of antitumor immunity (131)

Wild-type IDH1 maintains NSCLC stemness and chemoresistance through activation of the serine biosynthetic pathway

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While it decreases ROS generation by enhancing antioxidant enzyme activity, DPQ has also been associated with detrimental effects, including increased DNA damage and apoptosis in cardiomyocytes 170

Further, neither study fully accounted for medication use at the time of DNA collection