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___ AP video journalist Javier Arciga contributed to this story from San Diego ___ The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institutes Science and Educational Media Group and the Robert Wood Johnson Foundation

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Maitane Prez Argeso 1 , Nagore del Molino Urquijo 1 , Sal Silvarrey Rodrguez 1 , Begoa Huete Antn 1 , Juan Manuel Garcia Sanchez 1 , Borja Aguilera Irazabal 1 , Naroa Arenaza Basterrechea 1 , Juan Carlos Garca-Monco Carra 1 1 Hospital Universitario de Basurto, Bilbao, Spain Background and Aims: Mechanical thrombectomy (MT) has demonstrated significant benefits in patients meeting strict ESOC guidelines criteria: mRS1, large vessel occlusion (internal carotid artery, M1 segment of the middle cerebral artery or basilar artery), NIHSS6, ASPECTS6 and a door-to-needle time 6 hours or 24 hours with a favourable mismatch on multimodal CT

These trials represent the closest any T4-related compound has come to therapeutic development, though the program has not resulted in FDA approval as of February 2026