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More powerful dysregulation of Helicobacter pylori East Asian-type CagA on intracellular signalings

209 And a significant increase in -aminobutyric acid (GABA) and agmatine levels, without changes in glutamate levels, was observed in the hippocampus of rats subjected to a KD for 15 days compared to rats on a normal rat chow diet

The resulting histamine overload causes systemic inflammation, leading to classic MCAS symptoms like sudden hives, flushing, severe gastrointestinal distress, rapid heart rate (tachycardia), and sudden intolerances to previously safe foods

3.3.2 Metabolic regulatory functions of short-chain fatty acids (SCFAs) As the primary fermentation products of dietary fiber, SCFAs serve as core mediators of communication between gut microbiota and host metabolism