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Without being bound to a particular theory, the inventors hypothesized that RSLs, such as erastin, activate a lethal pathway that is different from apoptosis, necrosis and other well-characterized types of regulated cell death

Furthermore, we show that cystine-mediated NRF2 activation induces the expression of important genes involved in oxidative stress response, but also in epithelial-to-mesenchymal transition and stem-like phenotype

A certain polymorphism of GPR50 seems to be connected to an elevated risk of bipolar disorder, schizophrenia and major depression in women [71]

Gut microbial-related choline metabolite trimethylamine-N-Oxide is associated with progression of carotid artery atherosclerosis in HIV infection

However, with deepening insight with regard to the anticancer effect of Vit-C on the molecular level, these impasses may be overcome to take it from bench to bedside