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The docking results suggest that the positively charged guanidinium group of Arg240 interacts strongly with the carboxylate group of L -tyrosine and L -DOPA, whereas the amine group (which is predominantly positively charged at the investigated pH) of the other two substrates is electrostatically repelled (Fig

Third, increased inflammatory cytokines (e.g., IL-1, IL-6, TNF-, and IFN-) disrupt BBB integrity and induce neuroinflammation

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The HGH secreted from these cells may also play a role in the formation of insulin-like growth factor-1 (IGF-1)