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The most common cause of tertiary adrenal insufficiency is the chronic use of exogenous glucocorticoids (pharmacotherapy), leading to the suppression of hypothalamic secretions of CRH

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Thomas C, Gioiello A, Noriega L, Strehle A, Oury J, Rizzo G, et al

HUVECs exposed to Erastin presented an increase in intracellular levels of ROS ( Figure 1A ) and lipid peroxide levels ( Figure 1C ), without affecting mitochondrial ROS ( Figure 1B ) but decreasing the GSH levels ( Figure 1D )