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Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity

Abstract Aggressive and therapy-resistant cancers present a significant challenge to treatment and are associated with poor patients survival

Integrating ChIP-seq, HiC, and PRO-seq datasets, we revealed broad functional binding of NRF2 at enhancer elements, including NRF2-dependent enhancer-derived RNA (eRNA) synthesis and extensive linkages between NRF2 target promoters and enhancers

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In contrast, HIF2 KO cells showed increased synthesis of NADH, reflected as m + 5 isotopologues, while the intracellular levels of NADH were decreased, indicating enhanced utilization of this reduced co-factor (Fig