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This review comprehensively examines the molecular mechanisms by which mitochondria contribute to tumor radioresistance and critically discusses emerging mitochondria-targeted therapeutic strategies aimed at improving radiosensitivity

Hemophagocytic lymphohistiocytosis: an update on diagnosis and pathogenesis

If the substrate is deglutathionylated, the first stage proceeds by the monothiol mechanism, but the glutathionylated intermediate product Grx-SSG then releases GSH yielding the intramolecular disulfide bond Grx(S 2 ) between the catalytic cysteine residue and one of the recycling cysteines

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Although Nrf2 does not directly contribute to aerobic glycolysis, glucose uptake and glycolytic activity are stimulated under the sustained activation of the PI3KAkt signaling (Wieman et al., 2007), thereby increasing the supply of glycolytic intermediates