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The reciprocal interactions between gut microbiota and IECs are essential for maintaining immune homeostasis at the mucosal interface, orchestrating a balance between proinflammatory and tolerogenic responses [6]

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Inhibition of the group IVA phospholipase A 2 , reprogrammed metabolism and prevented T cell senescence, suggesting that unbalanced lipid metabolism could be a key driver of T cell senescence (Liu et al., 2021)