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RSL3 + Lip-1: n = 3 independent experiments

DRAK2 is a serine/threonine kinase of the death associated protein kinase (DAPK) family ( 2+ , regulates its catalytic activity ( Although broadly expressed at low levels ( Drak2 gene leads to hyperactive Ca 2+ mobilization in T cells, especially under suboptimal TCR stimulus conditions ( Drak2 gene leads to diminished autoimmune susceptibility, with reduced clinical severity observed in animal autoimmune models for multiple sclerosis (experimental autoimmune encephalomyelitis) and type I diabetes-prone non-obese diabetic (NOD) mice ( Using a mass spectrometry based approach, we determined that DRAK2 possesses several autophosphorylation sites, most notably Ser10, Ser12, and Ser351

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