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The oxidation states of the low-potential clusters are the oxidized [2Fe 3+ , 2Fe 2+ ] and the reduced [Fe 3+ , 3Fe 2+ ] forms, while the oxidation states for the high potential clusters switch between the reduced [2Fe 3+ , 2Fe 2+ ] and the oxidized [3Fe 3+ , Fe 2+ ] forms

Indeed, recent findings correlate the effects of curcumin on the Nrf2 pathway with its properties as an autophagy inducer since autophagy activation appears to be essential in regulating the effects of the Nrf2 pathway [123]

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This has led to the conclusion that under normal conditions, vitamin C helps safeguard the integrity of neurons (and therefore the brain), largely through neutralization of the free radicals of reactive oxygen species (ROS)

While mammals have only one copy of the GPX4 gene, fish have two copies, GPX4a and GPX4b