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362 Although nutlins have promising antitumor activity in tumors expressing wild-type p53, they have not been used in clinical applications because of their toxicity and poor bioavailability

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The interest in triggering of autoimmune conditions by viral infections was renewed during the coronavirus disease 2019 (COVID-19) pandemic when there were outbreaks of pediatric inflammatory multisystemic syndrome [PIMS also referred to as multisystem inflammatory syndrome in children (MIS-C)] that reportedly followed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children