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tissue and systemic milieuWith aging there is a drift which is re-calibrated by a number of rejuvenation approachesWhen an auto-inductive age-elevated ligand is diluted, it cannot activate its own receptor and induce its own mRNA, so ligand levels diminish to their younger states for prolonged time. The Conboys theorize that these harmful proteins are part of a positive feedback loop, in other words, a cycle that is self-sustaining epigenetic state gene expression translation to circulating proteins feedback that alters the epigenetic state With age, the body has slipped into a dysfunctional, self-sustaining cycle, and with the shock of disruption, they are able to nudge it back into a more robust and youthful cycle, also self-sustaining

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S16: Pa SAHH, Fig

doi: 10.1038/s41582-023-00885-0

Traditional medicine calls this normal and offers nothing