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Finally, it should be noted that while we have utilised CRISPR-Cas9 knockout and titrated lentiviral transduction of BioID-tagged rescue transgenes to allow as near to endogenous expression as technically possible, BioID tagging of the endogenous gene loci will allow endogenous tagging of proteins to further validate and extend the present findings

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These programs do not contain predefined model structures or differential equations, making the complexity and flexibility of the model dependent on the researchers objectives and programming capabilities

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