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doi: 10.1007/s00018-014-1744-7

32 The inner ear is rich in insulin receptors

In 1977, an expert panel convened by the FDA issued urgently worded advice, saying it was obligatory to put a warning on the drugs label that it could cause severe liver damage. After much debate, the FDA added the warning 32 years later

Precursor autoprocessing was partially inhibited at 10 nM DRV (lightest blue data points) and completely suppressed at concentrations above 100 nM (darker blue data points)