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Surgical Careful selection, patient education and discussion of patient expectation help to improve satisfaction post-surgery

Genetic predispositions, such as HLA-DRB1 alleles, increase RA risk by 2 - 3-fold, while environmental triggers like smoking and infections initiate immune dysregulation (7)

DOI: 10.1038/s41398-019-0497-3 12

Then, it will be worth considering an integrated functional approach to better understand the complex relationship between the KP and various other metabolic or immunological dysregulated pathways in ME/CFS