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Certain studies suggest that during EP, HO-1 not only plays a critical role in RBC detoxification and heme metabolism but also demonstrates antioxidant and anti-inflammatory properties (90)

Long-term efficacy studies indicate that many patients can achieve and maintain reasonable disease control with a continuous treatment methodology, especially when combined with folic acid supplementation to mitigate side effects

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96,97 TGF- also induces and promotes the increased expression of EGF, EGFR and its related signalling pathways, and their synergism induces EMT-related phenotypic changes