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Recently, the effects of SIRT1 on the biological functions of trophoblasts and endothelial cells have gradually emerged, and the expression of SIRT1 is lower in serum samples and placental tissues of pre-eclampsia patients

172 In one study that included 92 women and 46 men undergoing assisted reproductive treatment and 161 controls, MTHFR mutations were correlated with poor in vitro fertilization outcomes and embryonic chromosomal abnormalities