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In addition, there is a hybrid receptor with components of the IR (one and one -chain) and the IGF-1R (one and one -chain), to which both insulin and IGF-1 can bind to, but with less affinity than that of their putative receptors [9]

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To this end, several metabolic nodes can be targeted

Recent studies have confirmed that ferroptosis is associated with resistance to cancer treatment, and dysregulation of ferroptosis often leads to drug resistance and treatment failure