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MOTS-c is typically administered via subcutaneous injection into the abdomen, lateral thigh, or flank, rotating injection sites to prevent tissue accumulation

This is a legitimate basis for clinical use but a different evidence tier than RCT data

Lucas, V., Cavadas, C

What modern dermatological treatments do achieve is long-lasting improvement: a significantly lighter, more even skin tone that, with proper sun protection and periodic maintenance sessions, can be sustained for years

Methods: This retrospective observational analysis assessed the 1-year effect of CRNT on liver enzymes and liver-specific surrogate markers