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The first-pass effect describes a pharmacokinetic process in which a drug undergoes metabolism at a specific site in the body before reaching the systemic circulation or its intended site of action, which reduces the concentration of the active drug available [47]

We need to develop better therapies for prostate cancer patients, because most of these tumors develop resistance to hormone-based therapies doctors rely on to treat these cancers, said senior author Nupam P

Periodontology 2000(51):141151

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This involves the activation of caspases, cysteine-aspartic proteases that orchestrate cell dismantling by cleaving specific substrates