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Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration

Front Neurosci 12(APR):214 Wang H, Liu C, Zhao Y, Zhang W, Xu K, Li D et al (2020) Inhibition of LONP1 protects against erastin-induced ferroptosis in Pancreatic ductal adenocarcinoma PANC1 cells

However, these models are not amenable to high-throughput treatment screens

If you take a standard iron tablet and a standard glutathione capsule, much of that material may be destroyed by your stomach acid or filtered out by the liver before it ever reaches your systemic circulation