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Interaction of NAPQI with mitochondrial proteins and formation of mitochondrial protein adducts is thought to be critical for the toxicity [24-26]

doi: 10.1182/blood-2009-10-249540 41 FrauwirthKARileyJLHarrisMHParryRVRathmellJCPlasDRet al

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Notably, the protective effect of betaine is consistent across species and has been verified in various models, such as mice, rats, fish, and poultry, even demonstrating a preventive effect during the embryonic or maternal supplementation stages (80, 83, 88)

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