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Kaminski HJ, Kusner LL, Nash KV, Ruff RL

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Upon receptor binding, IGF1R undergoes autophosphorylation, initiating downstream signaling pathways, including: Phosphoinositide 3-kinase (PI3K)/Akt pathway Mitogen-activated protein kinase (MAPK) pathway These pathways are associated with intracellular signal transduction processes, including regulation of gene expression, protein translation, and cellular signaling dynamics at the molecular level

Venn diagram of the SG proteome identified after AS treatment, comparing in-house data with published datasets