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These act as electron carriers, catalyzing biochemical reactions to produce ROS, which destroy macromolecules such as DNA, proteins, lipids, even and organelles like mitochondria and lysosomes

Elevations in the plasma homocysteine concentration can occur due to genetic defects in the enzymes involved in homocysteine metabolism, to nutritional deficiencies in vitamin cofactors, or to other factors including some chronic medical conditions and drugs