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Beyond repurposing existing drugs, Nrf2 activators (e.g., Dimethyl Fumarate) are particularly promising as they upstreamly regulate a network of antioxidant genes, including SLC7A11, GPX4, HO-1, and FTH1, thus simultaneously bolstering defenses against multiple drivers of ferroptosis ( Table 2 ) (176)

They also included the coupling helices ICL5 and ICL7 and their associated TMs 10-11 and 14-15, respectively, due to their role in substrate transport 34,35

Thankfully, some dietary habits, like taking the right supplements, can help prevent issues