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Orthogonal therapies Two therapies are considered orthogonal if they target a cancer in two different ways such that a resistance mechanism for the first therapy is unlikely to suppress the activity of the second therapy and vice versa

Grant CM, Maciver FH, Dawes IW (1997) Glutathione synthetase is dispensable for growth under both normal and oxidative stress conditions in the yeast Saccharomyces cerevisiae due to an accumulation of the dipeptide y-glutamylcysteine