lysosome glutathione (GSH) is synthesized in the cytoplasm by the action of Mitochondria acidify lysosomes through membrane

Mitochondria acidify lysosomes through membrane contacts: Cell Reports S Glutathionylation: From Molecular Mechanisms to Health Outcomes PMC Ferroptosis regulation in lysosome Lysosomal iron and cathepsin B contribute to ferroptotic cell death. Lysosomal cyst(e)ine can be mobilized to maintain glutathione synthesis and glutathione peroxidase 4 activity, thereby limiting lipid peroxidation. Fine tuning phenoxy silyl scaffolds for the development of glutathione responsive prodrugs and antibodydrug conjugates ScienceDirect Glutathione: A Samsonian life sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation PMC

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