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In the liver, berberine treatments significantly increased the expression of peroxisome proliferator-activated receptor ( ppar ) and carnitine palmitoyltransferase 1 ( cpt-1 ) genes, leading to a reduction in lipid accumulation

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and (3) recycling of these forms to the reduced compounds by high-capacity enzyme-based systems that depend on the key elec- tron carriers, NAD(P)H

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