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Least absolute shrinkage and selection operator (LASSO) regression was conducted to detect important metabolites

As another important component of the opioid system, there are three main canonical opioid receptors, namely , , and opioid receptors (MOR, DOR, and KOR, respectively), which play important roles in various physiological and pathological functions of the body (Table 1), as well as the nociceptin/orphanin FQ receptor (NOR), which was previously known as opioid receptor-like-1, and are widely distributed in systemic cells [12,13]

Fatty liver, in which fat is deposited in the liver tissue, is thought to progress to non-alcoholic steatohepatitis and liver cirrhosis (NASH) when the tissue is exposed to certain stimuli such as oxidative stress and inflammatory cytokines

Methods: A total of 34 patients with biopsy-proven fatty liver disease (10 with ALD, 24 with NAFLD) were evaluated

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