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Rosenthal DI , Nurenberg P, Becerra CR, Frenkel EP, Carbone DP, Lum BL, Miller R, Engel J, Young S, Miles D, Renschler MF

Based on converging evolutionary and mechanistic evidenceencompassing mitochondrial centrality in hypoxic response, natural selection of the Tibetan-enriched mitochondrial DNA haplogroup M9a, and bidirectional ROS-HIF regulatory crosstalkwe propose a mechanistic hypothesis that mitochondrial retrograde signaling orchestrates nuclear genomic reprogramming through modulation of HIF-responsive elements to establish hypoxia-tolerant phenotypes

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Minich DM, Brown BI